A metabolite of DDT; an agonist at ERα and ERβ (REC20s = 3.2 and 2.4 µM

p,p’-DDD – 100 mg

Brand:
Cayman
CAS:
72-54-8
Storage:
-20
UN-No:
- 2811 / 6.1

p,p’-DDD is a metabolite of the organochlorine pesticide DDT.{36698} It is an agonist at estrogen receptor α (ERα) and ERβ, increasing transactivation with 20% relative effective concentrations (REC20) of 3.2 and 2.4 µM, respectively, in CHO-K1 cells expressing the human receptors.{42200} It inhibits DHT-induced androgen receptor transcription with a 20% relative inhibitory concentration (RIC20) of 0.71 µM. p,p’-DDD increases apoptosis in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 100 and 150 µg/ml.{36699} Blood levels of p,p’-DDD and the level of PBMC apoptosis are increased in children exposed to DDT compared with unexposed children. It is not considered lethal to hamsters (LD50 = ~5,000 mg/kg) but is to rats (LD50 = 3,750 mg/kg).{36700}  

 

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SKU: 24234 - 100 mg Category:

Description

A metabolite of DDT; an agonist at ERα and ERβ (REC20s = 3.2 and 2.4 µM, respectively); inhibits DHT-induced androgen receptor transcription (RIC20 = 0.71 µM); increases apoptosis in isolated human PBMCs at 100 and 150 µg/ml; not considered lethal to hamsters (LD50 = ~5,000 mg/kg) but is to rats (LD50 = 3,750 mg/kg)

Formal name: 1,1′-(2,2-dichloroethylidene)bis[4-chloro-benzene]

Synonyms:  p,p-Dichlorodiphenyldichloroethane|4,4′-DDD|4,4′-Dichlorodiphenyldichloroethane|NSC 8941

Molecular weight: 320

CAS: 72-54-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Toxicology|Environmental

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