A broad-spectrum triazole active against various yeasts and molds

Posaconazole – 1 mg

Brand:
Cayman
CAS:
171228-49-2
Storage:
-20
UN-No:
Non-Hazardous - /

Posaconazole is a broad-spectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes.{20805} Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC50s range from 7-200 nM), which results in a disruption the synthesis of ergosterol (Item No. 19850), a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.{24400}  

 

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Description

A broad-spectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes; inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase (IC50s range from 7-200 nM), a key enzyme in the synthesis of ergosterol

Formal name: 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol

Synonyms:  POS|SCH 56592

Molecular weight: 700.8

CAS: 171228-49-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases

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