An inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM

Porcupine-IN-1 – 1 mg

Brand:
Cayman
CAS:
2036044-77-4
Storage:
-20
UN-No:
Non-Hazardous - /

Porcupine-IN-1 is an inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays).{47087,47088} It inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells when used at a concentration of 0.1 μM, indicating inhibition of porcupine, an enzyme that catalyzes palmitoylation of Wnt proteins.{47087}  

 

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SKU: 25834 - 1 mg Category:

Description

An inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays); inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells at 0.1 μM, indicating inhibition of porcupine

Formal name: N-[(3-fluoro-2′-methyl[2,4′-bipyridin]-5-yl)methyl]-9H-carbazole-2-carboxamide

Synonyms:  PORCN-IN-1

Molecular weight: 410.4

CAS: 2036044-77-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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