A steroid saponin with anticancer activity; decreases proliferation of

Polyphyllin I – 25 mg

Brand:
Cayman
CAS:
50773-41-6
Storage:
-20
UN-No:
- /

Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity.{47762} It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 µM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells.{47763} Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.{47762}  

 

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SKU: 29179 - 25 mg Category:

Description

A steroid saponin with anticancer activity; decreases proliferation of, and apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 µM, respectively); disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of PARP in HepG2 and R-HepG2 cells; reduces tumor growth in an MCF-7 mouse xenograft model at 2.05 and 2.73 mg/kg for 10 days

Formal name: (3β,25R)-spirost-5-en-3-yl O-α-L-arabinofuranosyl-(1→4)-O-[6-deoxy-α-L-mannopyranosyl-(1→2)]-β-D-glucopyranoside

Synonyms:  (+)-Polyphyllin D

Molecular weight: 855

CAS: 50773-41-6

Purity: ≥95%

Formulation: A solid

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