Differs from polymyxin B1 by having isoleucine rather than leucine as a component of the cyclic peptide; comparable to other B polymyxins in its ability to kill P. aeruginosa

Polymyxin B1 Isoleucine – 500 µg

Brand:
Cayman
CAS:
80469-10-9
Storage:
-20
UN-No:
Non-Hazardous - /

The polymyxins are cationic peptides originally isolated from B. polymyxa.{22080} They bind and kill Gram-negative bacteria.{22081} The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B1 Isoleucine differs from polymyxin B1 by having isoleucine rather than leucine as a component of the cyclic peptide. Polymyxin B1 isoleucine is comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.{22082} Its relative pharmacokinetics and nephrotoxicity have not been examined.  

 

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Description

Differs from polymyxin B1 by having isoleucine rather than leucine as a component of the cyclic peptide; comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates

Formal name: N-((S)-4-amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-12-((S)-sec-butyl)-3-((R)-1-hydroxyethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide

Synonyms: 

Molecular weight: 1,203.50

CAS: 80469-10-9

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Polypeptides||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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