A pyranone with antifungal and insecticidal activities; active against a laboratory strain and clinical isolates of C. albicans (MICs = 49 and 12-97 µg/ml

Pogostone – 10 mg

Brand:
Cayman
CAS:
23800-56-8
Storage:
-20
UN-No:
Non-Hazardous - /

Pogostone is a pyranone that has been found in the essential oil of P. cablin, also known as patchouli oil, and has antifungal and insecticidal activities.{51079} It is active against a laboratory strain and clinical isolates of C. albicans (MICs = 49 and 12-97 µg/ml, respectively). It reduces fungal load in the vagina in a mouse model of fluconazole-resistant vulvovaginal candidiasis when administered at topical doses of 1, 2, and 4 mg/kg per day or oral doses of 20, 40, and 80 mg/kg per day.{51080} Pogostone is toxic to S. exigua and S. litura larvae with LC50 values of 545.61 and 986.88 mg/L for dietary administration and 519.48 and 1,041.42 mg/L for contact application.{51081} It also has antifeedant activity against third instar larvae against S. exigua and S. litura.  

 

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SKU: 27812 - 10 mg Category:

Description

A pyranone with antifungal and insecticidal activities; active against a laboratory strain and clinical isolates of C. albicans (MICs = 49 and 12-97 µg/ml, respectively); reduces fungal load in the vagina in a mouse model of fluconazole-resistant vulvovaginal candidiasis at 1, 2, and 4 mg/kg per day topically or 20, 40, and 80 mg/kg per day orally; toxic to S. exigua and S. litura larvae with LC50 values of 545.61 and 986.88 mg/L for dietary administration and 519.48 and 1,041.42 mg/L for contact application

Formal name: 4-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2H-pyran-2-one

Synonyms: 

Molecular weight: 224.3

CAS: 23800-56-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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