Description
Podoplanin is a mucin type-1 glycoprotein of 40-43. Podoplanin is expressed in many tumors and many normal cells, especially lymphatic epithelial cells and follicular DCs. It appears to serve as a ligand for CLEC-2. Podoplanin expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue.{19761,19762,19763} It has also been determined that podoplanin expression is induced through Src activation of Cas.{19760} Recently there are indications of podoplanin presence on Th17 cells.{19759} Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC.
Synonyms: Aggrus|gp38|T1A
Immunogen:
Formulation: 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Isotype:
Applications: FC and WB
Origin: Animal/Rat
Stability: 180 days
Application|Flow Cytometry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity
