A non-alkaloid toxin lignan that blocks tubulin polymerization

Podophyllotoxin – 250 mg

Brand:
Cayman
CAS:
518-28-5
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species.{31220,29603} It binds to topoisomerase II during the late S and early G2 stage, blocking tubulin polymerization and, thus, inhibiting mitosis. In addition to being used as a cathartic, purgative, antiviral agent, vesicant, and antihelminthic, podophyllotoxin is the starting material for the semi-synthesis of the anti-cancer drugs etoposide (Item No. 12092), teniposide (Item No. 14425), and etopophos.{31220,29603}  

 

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Description

A non-alkaloid toxin lignan that blocks tubulin polymerization, thus, inhibiting mitosis; used as a cathartic, purgative, antiviral agent, vesicant, antihelminthic and the starting material for the semi-synthesis of the anti-cancer drugs etoposide, teniposide, and etopophos

Formal name: (5R,5aR,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Synonyms:  NSC 24818|PPT

Molecular weight: 414.4

CAS: 518-28-5

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Toxins||Research Area|Cancer||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases||Research Area|Infectious Disease|Viral Diseases

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