A positive allosteric modulator of the α7 neuronal nAChR

PNU-120596 – 5 mg

Brand:
Cayman
CAS:
501925-31-1
Storage:
-20
UN-No:
Non-Hazardous - /

PNU-120596 is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM).{29718} It has no detectable effect on α4β2, α3β4, or α9β10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats.{29718,29720} It also reduces the cortical/subcortical infarct volume caused by transient focal cerebral ischemia in rats.{29719}  

 

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Description

A positive allosteric modulator of the α7 neuronal nAChR, increasing agonist-evoked calcium flux (EC50 = 216 nM); increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats

Formal name: N-(5-chloro-2,4-dimethoxyphenyl)-N’-(5-methyl-3-isoxazolyl)-urea

Synonyms:  NSC 216666

Molecular weight: 311.7

CAS: 501925-31-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Neuroprotection|Ischemia

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