An oxazolidinone antibiotic that is active against multidrug resistant tuberculosis; inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid

PNU 100480 – 25 mg

Brand:
Cayman
CAS:
168828-58-8
Storage:
-20
UN-No:
Non-Hazardous - /

PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis.{46435} It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid (Item No. 20378), rifampin (rifampicin; Item No. 14423), ethambutol (Item No. 23713), and streptomycin (Item No. 21211; MICs = ≤0.0625-0.5 mg/L).{46435,46436} It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml).{46437} PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.{46436}  

 

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SKU: 28395 - 25 mg Category:

Description

An oxazolidinone antibiotic that is active against multidrug resistant tuberculosis; inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid, rifampicin, ethambutol, and streptomycin (MICs = ≤0.0625-0.5 mg/L); inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml); decreases the number of CFUs in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection at 100 mg/kg per day

Formal name: N-[[(5S)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide

Synonyms:  Sutezolid|U 100480

Molecular weight: 353.4

CAS: 168828-58-8

Purity: ≥98%

Formulation: A crystalline solid

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