A potent reversible FAK inhibitor (IC50 = 1.5 nM against the recombinant enzyme and 100 nM in breast carcinoma cells)

PND1186 – 5 mg

Brand:
Cayman
CAS:
1061353-68-1
Storage:
-20
UN-No:
Non-Hazardous - /

PND1186 is a potent reversible focal adhesion kinase (FAK) inhibitor with an IC50 value of 1.5 nM against the recombinant enzyme and 100 nM in breast carcinoma cells.{32667} It promotes 4T1 breast carcinoma and ID8 ovarian carcinoma cell apoptosis when grown in anchorage-independent 3D cultures but had limited efficacy in 2D cultures. It is orally bioavailable, reducing orthotopic breast cancer tumor growth in mouse models.{32668}  

 

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Description

A potent reversible FAK inhibitor (IC50 = 1.5 nM against the recombinant enzyme and 100 nM in breast carcinoma cells)

Formal name: 2-[[2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methyl-benzamide

Synonyms:  SR 2516|VS-4718

Molecular weight: 501.5

CAS: 1061353-68-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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