A potent antagonist of C5aR (IC50 = 31 nM); orally active and brain penetrant; blocks inflammatory signaling and symptoms in animal models of colitis

PMX-205 – 500 µg

Brand:
Cayman
CAS:
514814-49-4
Storage:
-20
UN-No:
Non-Hazardous - /

PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50 = 31 nM).{33561} It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.{33559,33562} PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer’s disease.{33558}  

 

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Description

A potent antagonist of C5aR (IC50 = 31 nM); orally active and brain penetrant; blocks inflammatory signaling and symptoms in animal models of colitis, allergic asthma, and Alzheimer’s disease

Formal name: (5→1)-lactam-N2-(1-oxo-3-phenylpropyl)-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-L-arginine

Synonyms: 

Molecular weight: 839.1

CAS: 514814-49-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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