A natural 1

Plumbagin – 500 mg

Brand:
Cayman
CAS:
481-42-5
Storage:
-20
UN-No:
De Minimis - 2923 / 8|6.1

Plumbagin is a natural 1,4-naphthoquinone first isolated from plants of the genus Plumbago. It has diverse effects in cells and animals. Plumbagin causes the generation of reactive oxygen species and induces apoptosis in cancer cells.{28824,25057} It activates signaling through Nrf2 and the antioxidant response element, inducing the expression of Nrf2 target genes, including NQO1 and heme oxygenase-1 in cultured neuronal cells.{28824} Plumbagin also inhibits NADPH oxidase 4 in a time- and dose-dependent manner.{28825} It can be protective against peroxide stress or deprivation of glucose or oxygen.{28824}  

 

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Description

A natural 1,4-naphthoquinone that has diverse effects in cells and animals; causes the generation of ROS and induces apoptosis in cancer cells; activates signaling through Nrf2 and ARE, inducing the expression of Nrf2 target genes, including NQO1 and HO-1 in cultured neuronal cells

Formal name: 5-hydroxy-2-methyl-1,4-naphthalenedione

Synonyms:  NSC 236613|NSC 688284

Molecular weight: 188.2

CAS: 481-42-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Naphthoquinones||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Tumor Microenvironment||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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