An antagonist of CXCR4 (IC50s = 0.02-0.13 µg/ml); selective for CXCR4 over CXCR1-3 and CXCR5-9 (IC50s = >25 µg/ml); decreases infectious virus content in the supernatant of Jurkat cells chronically infected with HIV-1(IIIB) (EC50 = ~0.02 µg/ml); mobilizes murine and human hematopoietic stem and murine long-term repopulating cells for transplantation; increases T cell trafficking in mouse blood

Plerixafor (hydrochloride hydrate) – 50 mg

Brand:
Cayman
CAS:
155148-31-5
Storage:
-20
UN-No:
Non-Hazardous - /

The α-chemokine receptor, CXCR4, on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. In mammalian cell signaling, CXCR4 activation promotes the homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Plerixafor is a partial antagonist of chemokine receptor 4 (CXCR4) with IC50 values ranging from 0.02 to 0.13 µg/ml for inhibiting calcium flux in peripheral blood mononuclear cells (PBMCs), various types of T cells, and mouse lymphocytic leukemia cells.{42569} It is selective for CXCR4 over CXCR1-3 and CXCR5-9 (IC50s = >25 µg/ml). Plerixafor decreases infectious virus content in the supernatant of Jurkat cells chronically infected with HIV-1(IIIB) (EC50 = ~0.02 µg/ml).{16446} It rapidly mobilizes murine and human hematopoietic stem and murine long-term repopulating cells for transplantation alone and, with a synergistic effect, when used in combination with G-CSF.{15446} Plerixafor also increases T cell trafficking in mouse blood, spleen, and central nervous system.{16445,16447} Plerixafor (1.25 mg/kg twice per day) decreases the number of 4T1 murine mammary carcinoma cells in the lung in a mouse model of lung metastasis.{15450}  

 

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SKU: 10011332 - 50 mg Category:

Description

An antagonist of CXCR4 (IC50s = 0.02-0.13 µg/ml); selective for CXCR4 over CXCR1-3 and CXCR5-9 (IC50s = >25 µg/ml); decreases infectious virus content in the supernatant of Jurkat cells chronically infected with HIV-1(IIIB) (EC50 = ~0.02 µg/ml); mobilizes murine and human hematopoietic stem and murine long-term repopulating cells for transplantation; increases T cell trafficking in mouse blood, spleen, and central nervous system; decreases the number of 4T1 murine mammary carcinoma cells in the lung in a mouse model of lung metastasis at 1.25 mg/kg twice per day

Formal name: 1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene, octahydrochloride

Synonyms:  AMD 3100|JM 3100|SID 791

Molecular weight: 794.5

CAS: 155148-31-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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