An antipicornaviral agent; inhibits Picornaviridae viral replication; inhibits replication of HRV-A2 and HRV-B14 in HeLa Rh cells (EC50s = 0.1 and 0.3 μM

Pleconaril – 50 mg

Brand:
Cayman
CAS:
153168-05-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Pleconaril is an antipicornaviral agent.{52019, 52020} It inhibits Picornaviridae viral replication by binding to a hydrophobic pocket in the major VP1 capsid protein, which prevents uncoating of the viral RNA genome. Pleconaril inhibits replication of the rhinoviruses HRV-A2 and HRV-B14 in HeLa Rh cells (EC50s = 0.1 and 0.3 μM, respectively) and is not cytotoxic to HeLa Rh cells with a 50% cytotoxic concentration (CC50) of greater than 131 μM.{52020} It also inhibits replication of enterovirus 71 (EV71) in human rhabdomyosarcoma (RD) cells (EC50 = 15 μM) and is not cytotoxic to RD cells (CC50 = >131 μM). Pleconaril (80 mg/kg per day) increases survival of EV71-infected mouse pups from 20 to 80%.{52021}  

 

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SKU: 28461 - 50 mg Category:

Description

An antipicornaviral agent; inhibits Picornaviridae viral replication; inhibits replication of HRV-A2 and HRV-B14 in HeLa Rh cells (EC50s = 0.1 and 0.3 μM, respectively) and is not cytotoxic to HeLa Rh cells (CC50 = >131 μM); inhibits replication of EV71 in RD cells (EC50 = 15 μM) and is not cytotoxic to RD cells (CC50 = >131 μM); increases survival of EV71-infected mouse pups from 20 to 80% at 80 mg/kg per day

Formal name: 3-[3,5-dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole

Synonyms:  VP 63843|Win 63843

Molecular weight: 381.4

CAS: 153168-05-9

Purity: ≥98%

Formulation: A crystalline solid

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