An antibiotic that selectively inhibits cellular lipid biosynthesis (IC50 = 0.1 μM) by targeting FabF/B

Platensimycin – 250 µg

Brand:
Cayman
CAS:
835876-32-9
Storage:
-20
UN-No:
Non-Hazardous - /

Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM).{25106} It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively).{25106} By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance.{25108} PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg.{25107}  

 

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Description

An antibiotic that selectively inhibits cellular lipid biosynthesis (IC50 = 0.1 μM) by targeting FabF/B, an enzyme important for the biosynthesis of fatty acids; also inhibits mammalian fatty acid synthase, which reduces liver triglyceride levels and improves insulin sensitivity in a diabetic mouse model

Formal name: 3-[[3-[(1S,3S,4S,9S)-1,4,5,8,9,9aR-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5aS-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-benzoic acid

Synonyms:  PTM

Molecular weight: 441.5

CAS: 835876-32-9

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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