Plantamajoside – 10 mg

Brand:
Cayman
CAS:
104777-68-6
Storage:
-20
UN-No:
Non-Hazardous - /

Plantamajoside is a phenylethanoid that has been found in P. lanceolata and has diverse biological activities, including antioxidative, anticancer, and anti-inflammatory properties.{45282,45283,45284} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 11.8 µM). It also inhibits 5-lipoxygenase (5-LO) and 15-LO (IC50s = 0.375 and 96 µM, respectively).{45282,45283} Plantamajoside decreases viability of TE-1 esophageal squamous cell carcinoma (ESCC) cells when used at concentrations ranging from 20 to 320 µg/ml, as well as inhibits LPS-induced epithelial-to-mesenchymal transition (EMT) in Eca-109 and TE-1 cells and decreases phosphorylated NF-κB levels in TE-1 cells.{45284} Plantamajoside (3 mg/ear) inhibits mouse ear edema induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) by 25%.{45282}  

 

Available on backorder

SKU: 27296 - 10 mg Category:

Description

A phenylethanoid with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 11.8 µM); inhibits 5- and 15-LO (IC50s = 0.375 and 96 µM, respectively); decreases viability of TE-1 ESCC cells at 20-320 µg/ml, as well as inhibits LPS-induced EMT in Eca-109 and TE-1 cells and decreases phosphorylated NF-κB levels in TE-1 cells; inhibits arachidonic acid-induced mouse ear edema at 3 mg/ear


Formal name: 2-(3,4-dihydroxyphenyl)ethyl 3-O-β-D-glucopyranosyl-β-D-glucopyranoside 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Synonyms: 

Molecular weight: 640.6

CAS: 104777-68-6

Purity: ≥95%

Formulation: A crystalline solid


Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators||Research Area|Lipid Biochemistry||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic