A macrocyclic lactone that selectively binds SF3b and inhibits mRNA splicing; potently blocks the growth of proliferating cells with mean IC50 values of 1.6 nM for six gastric cancer cell lines

Pladienolide B – 500 µg

Brand:
Cayman
CAS:
445493-23-2
Storage:
-20
UN-No:
Non-Hazardous - /

Spliceosomes mediate the processing of pre-mRNA into mature mRNA.{27002,27000} Each spliceosome is a multiunit complex containing several proteins and RNA molecules that work in unison to repeatedly cleave and rejoin segments of mRNA.{27002, 27000} Pladienolide B is a macrocyclic lactone that selectively binds splicing factor 3b and inhibits mRNA splicing.{27003,27004} Through this action, pladienolide B potently blocks the growth of proliferating cells with mean IC50 values of 1.6 nM for six gastric cancer cell lines.{27005,27001} In xenograft tumors generated in mice using human cancer cells, pladienolide B blocks mRNA splicing and induces apoptosis, clearing tumors within two weeks after treatment.{27001}  

 

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Description

A macrocyclic lactone that selectively binds SF3b and inhibits mRNA splicing; potently blocks the growth of proliferating cells with mean IC50 values of 1.6 nM for six gastric cancer cell lines

Formal name: (4R,7R,8S,9E,11S,12S)-8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-oxacyclododec-9-en-2-one

Synonyms: 

Molecular weight: 536.7

CAS: 445493-23-2

Purity: ≥95%

Formulation: A clear film

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis

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