Description
A dual inhibitor of PI3K and mTOR (IC50s = 1.4, 9.2, and 1.7 nM for PI3Kα, PI3Kγ, and mTOR, respectively); reduces proliferation of MDA-MB-361 and PC3 cancer cells (IC50s = 8 and 21 nM, respectively); inhibits phosphorylation of Akt in MDA-MB-361 cells (IC50 = 5 nM); reduces intratumor phosphorylation of Akt and tumor growth in an MDA-MB-361 mouse xenograft model at 25, 50, and 100 mg/kg; inhibits tumor growth in U87MG glioma and A549 lung cancer mouse xenograft models
Formal name: N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N’-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-urea
Synonyms:
Molecular weight: 570.6
CAS: 1173204-81-3
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling
