A PKGIα activator; induces relaxation in U-46619-precontracted mesenteric arteries isolated from wild-type

PKG Drug G1 – 100 mg

Brand:
Cayman
CAS:
374703-78-3
Storage:
-20
UN-No:
Non-Hazardous - /

PKG drug G1 is an activator of protein kinase GIα (PKGIα).{46709} It induces relaxation in U-46619-precontracted mesenteric arteries isolated from wild-type, but not oxidation-insensitive Cys42Ser PKGIα knock-in, mice in a concentration-dependent manner. PKG drug G1 (14.8 mg/kg) induces oxidation of PKGIα, a marker of activation, in the aorta in a mouse model of angiotensin II-induced hypertension. It decreases mean arterial pressure in the same model when administered at a dose of 20 mg/kg per day for four days.  

 

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SKU: 29768 - 100 mg Category:

Description

A PKGIα activator; induces relaxation in U-46619-precontracted mesenteric arteries isolated from wild-type, but not oxidation-insensitive Cys42Ser PKGIα knock-in, mice in a concentration-dependent manner; induces oxidation of PKGIα in the aorta in a mouse model of angiotensin II-induced hypertension at 14.8 mg/kg; decreases mean arterial pressure in the same model at 20 mg/kg per day for 4 days

Formal name: 5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-4-imidazolidinone

Synonyms: 

Molecular weight: 257.3

CAS: 374703-78-3

Purity: ≥98%

Formulation: A crystalline solid

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