A synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM)

PKA Inhibitor (5-24) – 5 mg

Brand:
Cayman
CAS:
99534-03-9
Storage:
-20
UN-No:
Non-Hazardous - /

PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.{26247} It mimics the protein substrate by binding to the catalytic site through the arginine-cluster basic subsite.{26247} The prominent enzyme-substrate interaction site occurs where PKA catalytic subunit residues Tyr235 and Phe239 form a sandwich-like structure with residue Phe10 of PKI (5-24).{26246}  

 

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Description

A synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM)

Formal name: L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-a-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid

Synonyms:  PKI (5-24)|Protein Kinase A Inhibitor (5-24)

Molecular weight: 2,222.40

CAS: 99534-03-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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