Description
A K2P9.1/TASK-3 inhibitor (IC50 = 0.035 µM); selective for K2P9.1/TASK-3 over K2P2.1/TREK1 and Kv1.5 (IC50s = ~5 and >10 µM, respectively), as well as a panel of more than 100 receptors, ion channels, and enzymes at 10 µM but does inhibit K2P3.1/TASK-1 (IC50 = 0.3 µM); increases the time spent awake and decreases the duration of REM and delta sleep in mice at 100 mg/kg
Formal name: 1-[1-[6-([1,1′-biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
Synonyms:
Molecular weight: 468.6
CAS: 1332454-07-5
Purity: ≥98%
Formulation: A crystalline solid
