An inhibitor of PARPs which can be used in cells or in animals; binds and inhibits the PARP TNKS1 (IC50 = 1 μM); inhibits MMP-2 when used at higher concentrations (IC50 = 56 μM)

PJ-34 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
344458-15-7
Storage:
-20
UN-No:
Non-Hazardous - /

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.{22577,22591} PJ-34 is an inhibitor of PARPs which can be used in cells or in animals.{22593,22588,22592} It binds and inhibits the PARP tankyrase1 (IC50 = 1 μM).{22590} PJ-34 also inhibits matrix metalloproteinase-2 when used at higher concentrations (IC50 = 56 μM).{20001}  

 

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Description

An inhibitor of PARPs which can be used in cells or in animals; binds and inhibits the PARP TNKS1 (IC50 = 1 μM); inhibits MMP-2 when used at higher concentrations (IC50 = 56 μM)

Formal name: N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-acetamide, monohydrochloride

Synonyms: 

Molecular weight: 331.8

CAS: 344458-15-7

Purity: ≥98%

Formulation: A white to light brown powder

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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