An aza-anthracenedione analog that intercalates in DNA

Pixantrone (maleate) – 25 mg

Brand:
Cayman
CAS:
144675-97-8
Storage:
-20
UN-No:
Non-Hazardous - /

Pixantrone is an aza-anthracenedione analog that intercalates in DNA, directly alkylates DNA, and forms stable DNA adducts.{32717} It has demonstrated significant activity in preclinical models of solid tumors and hematologic malignancies.{32717,32715} Pixantrone has revealed little or no measurable cardiotoxicity in several animal models.{32717,32715} It also prevents acute experimental allergic encephalomyelitis development in animal studies, suggesting value in multiple sclerosis.{32716}  

 

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Description

An aza-anthracenedione analog that intercalates in DNA, directly alkylates DNA, and forms stable DNA adducts; has demonstrated significant activity in preclinical models of solid tumors and hematologic malignancies

Formal name: 6,9-bis[(2-aminoethyl)amino]-benz[g]isoquinoline-5,10-dione, dimaleate

Synonyms:  BBR 2778

Molecular weight: 557.5

CAS: 144675-97-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents

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