Description
A bacterial metabolite; binds to tubulin (Kd = 0.33 μM); increases the CrC for tubulin assembly in GAB at 25 μM; induces G2/M phase cell cycle arrest in 3Y1 rat fibroblasts at 50 ng/ml; induces apoptosis in HL-60 human leukemia cells at 33 nM; inhibits the growth of HT-29 human colorectal and MCF-7 human breast cancer cells (IC50s = 6.4 and 6 nM, respectively) but also of non-cancerous human HEK-293 cells (IC50 = 17 nM); inhibits the growth of A2780 human ovarian carcinoma cells, as well as of the drug-resistant, P-glycoprotein-expressing A2780AD subline (IC50s = 8 and 25 nM, respectively); decreases the generation of cytotoxic T lymphocytes in mice in response to immunization by allogeneic mouse EL4 T lymphocytes at 5 mg/kg; inhibits rice plant growth by 23% when applied nine days prior to heading
Formal name: (5R,6R)-5-ethyl-5,6-dihydro-6-[(2R,3S,4R,5S,7E)-2-hydroxy-4-methoxy-3,5-dimethyl-7-nonen-1-yl]-2H-pyran-2-one
Synonyms: (–)-Pironetin|NK 10958|NL 9C|PA 48153c
Molecular weight: 324.5
CAS: 151519-02-7
Purity: ≥70%
Formulation: A solid
