A quinolone antibiotic; active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 µg/ml

Piromidic Acid – 1 g

Brand:
Cayman
CAS:
19562-30-2
Storage:
-20
UN-No:
Non-Hazardous - /

Piromidic acid is a quinolone antibiotic that is active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 µg/ml, respectively).{36759,36760} It inhibits growth of nalidixic acid-sensitive strains of E. coli in an in vitro model of bacterial cystitis when used at concentrations of 10 and 50 mg/L.{36760} Piromidic acid also has antimalarial properties and is active against chloroquine-sensitive and -resistant strains of P. falciparum in vitro (IC50s = 41.4 and 14.4 µg/ml, respectively) as well as against hepatic stages of P. yoelii yoelii (IC50 = 21.6 µg/ml).{36761}  

 

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Description

A quinolone antibiotic; active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 µg/ml, respectively); inhibits growth of nalidixic acid-sensitive strains of E. coli in an in vitro model of bacterial cystitis at 10 and 50 mg/L; active against chloroquine-sensitive and -resistant strains of P. falciparum in vitro (IC50s = 41.4 and 14.4 µg/ml, respectively) and against hepatic stages of P. yoelii yoelii (IC50 = 21.6 µg/ml)

Formal name: 8-ethyl-5,8-dihydro-5-oxo-2-(1-pyrrolidinyl)-pyrido[2,3-d]pyrimidine-6-carboxylic acid

Synonyms:  NSC 291120

Molecular weight: 288.3

CAS: 19562-30-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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