A selective and reversible MAO-A inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A

Pirlindole – 10 mg

Brand:
Cayman
CAS:
60762-57-4
Storage:
-20
UN-No:
Non-Hazardous - /

Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).{38285} It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons.{38286} Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 µM independent of MAO-A activity.{38287}  

 

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Description

A selective and reversible MAO-A inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively); selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively); reverses the depressive-like effects induced by CMS, increases hippocampal cell proliferation, and reverses CMS-induced dendritic atrophy in granule neurons in rats; inhibits enterovirus-D68 and CV-B3; inhibits CV-B3 genome replication (EC50 = 7.7 µM),

Formal name: 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole

Synonyms: 

Molecular weight: 226.3

CAS: 60762-57-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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