A dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM

Pirinixic Acid Aminothiazole – 10 mg

Brand:
Cayman
CAS:
1492060-44-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Item No. 14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer.{12243,16854} Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively).{24884} It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms.{24884} Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 (Item No. 20210) during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.{24884}  

 

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Description

A dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively); reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response

Formal name: 2-[[4-chloro-6-[[4-(2-naphthalenyl)-2-thiazolyl]amino]-2-pyrimidinyl]thio]-octanoic acid

Synonyms: 

Molecular weight: 513.1

CAS: 1492060-44-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Prostaglandin Synthases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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