Description
An orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities; inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner; inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 at 300 mg/kg in lung in a mouse model of pulmonary fibrosis induced by bleomycin; inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 in a mouse model of NASH at 280 mg/kg; inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively)
Formal name: 5-methyl-1-phenyl-2(1H)-pyridinone
Synonyms: AMR 69
Molecular weight: 185.2
CAS: 53179-13-8
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic
