An anthracycline with anticancer activity; interacts with topoisomerase II; inhibits the growth of human HeLa and C33A cervical

Pirarubicin – 10 mg

Brand:
Cayman
CAS:
72496-41-4
Storage:
-20
UN-No:
Non-Hazardous - /

Pirarubicin is an anthracycline that has anticancer activity.{48552} It interacts with topoisomerase II to inhibit DNA replication. Pirarubicin inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively).{48553} It inhibits the growth of human Huh7 and MHCC97H liver cancer cells (IC50s = 0.159 and 0.374 μM, respectively).{48554} Pirarubicin also inhibits the growth of M5076 mouse ovarian cancer cells in vitro (IC50 = 0.366 μM) and in vivo in a mouse allograft model when administered at a dose of 2 mg/kg for four days.{48555}  

 

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SKU: 28384 - 10 mg Category:

Description

An anthracycline with anticancer activity; interacts with topoisomerase II; inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively); inhibits the growth of human Huh7 and MHCC97H liver cancer cells (IC50s = 0.159 and 0.374 μM, respectively); inhibits the growth of mouse M5076 ovarian cancer cells in vitro (IC50 = 0.366 μM) and in vivo in a mouse allograft model at 2 mg/kg for four days

Formal name: (8S,10S)-10-[[3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

Synonyms: 

Molecular weight: 627.6

CAS: 72496-41-4

Purity: ≥95%

Formulation: A solid

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