A synergist used to enhance the activity of insecticides; inhibits cytochrome P450 enzyme activity; increases the toxicity of deltamethrin to field-collected

Piperonyl Butoxide – 50 mg

Brand:
Cayman
CAS:
51-03-6
Storage:
-20
UN-No:
De Minimis - 3082 / 9

Piperonyl butoxide is a synergist used to enhance the activity of insecticides, including pyrethrin insecticides, through inhibition of cytochrome P450 enzymes (CYPs).{37755,37756} It increases the toxicity of the pyrethroid insecticide deltamethrin (Item No. 24172) to field-collected, deltamethrin-resistant strains of the bed bug C. lectularius by 40- to 176-fold when used at a concentration of 50 μg/μL.{37756} Piperonyl butoxide also increases the toxicity of the organotin insecticide Plictran to fourth instar larvae of susceptible strains of the cotton leafworm S. littoralis (LD50s = 0.78 and 40 μg/larva with and without piperonyl butoxide, respectively), as well as field strains (LD50s = 0.015 and 1.1 μg/larva with and without piperonyl butoxide, respectively).{43336} It is not toxic to the freshwater invertebrates H. azteca, C. tentans, and L. variegatus (LC50s = 530, 2,740, and 3,540 μg/L, respectively) and reduces the toxicity of the organophosphate pesticides diazinon (Item No. 23769), chlorpyrifos (Item No. 21412), and azinphos-methyl, which require activation by CYP enzymes in these organisms.{37755} Formulations containing piperonyl butoxide have been used for the control of agricultural, household, and veterinary pests.  

 

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SKU: 25820 - 50 mg Category:

Description

A synergist used to enhance the activity of insecticides; inhibits cytochrome P450 enzyme activity; increases the toxicity of deltamethrin to field-collected, deltamethrin-resistant strains of the bed bug C. lectularius by 40- to 176-fold at 50 μg/μL; increases the toxicity of Plictran to fourth instar larvae of susceptible strains of the cotton leafworm S. littoralis (LD50s = 0.78 and 40 μg/larva with and without piperonyl butoxide, respectively), as well as field strains (LD50s = 0.015 and 1.1 μg/larva with and without piperonyl butoxide, respectively); not toxic to the freshwater invertebrates H. azteca, C. tentans, and L. variegatus (LC50s = 530, 2,740, and 3,540 μg/L, respectively); reduces the toxicity of diazinon, chlorpyrifos, and azinphos-methyl in these organisms

Formal name: 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole

Synonyms:  NSC 8401

Molecular weight: 338.4

CAS: 51-03-6

Purity: ≥95%

Formulation: A liquid

Product Type|Biochemicals|Pesticides||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Environmental|Agriculture||Research Area|Toxicology|Environmental|Aquatic Systems

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