A natural alkaloid that activates TRPV1 (EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM); inhibits MAOs (IC50s = 21 and 7 µM for MAO-A and MAO-B

Piperine – 25 g

Brand:
Cayman
CAS:
94-62-2
Storage:
-20
UN-No:
Non-Hazardous - /

Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM).{27597,27596} At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for MAO-A and MAO-B, respectively.{27595} Like other natural compounds containing methylenedioxyphenyl substituents, piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver.{25115} It also has a biphasic effect on P-glycoprotein activity.{25373}  

 

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SKU: 11750 - 25 g Category:

Description

A natural alkaloid that activates TRPV1 (EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM); inhibits MAOs (IC50s = 21 and 7 µM for MAO-A and MAO-B, respectively; inhibits CYP3A species (Ki ~ 5 µM) and increases expression of CYP1A and CYP2B in liver

Formal name: (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-2,4-pentadien-1-one

Synonyms:  Bioperine|N-Piperoylpiperidin|NSC 21727

Molecular weight: 285.3

CAS: 94-62-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Neuroscience

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