A natural methylated diketopiperazine that potentiates the cytotoxicity of vincristine; directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil

Piperafizine A – 5 mg

Brand:
Cayman
CAS:
130603-59-7
Storage:
-20
UN-No:
Non-Hazardous - /

Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium.{31094} It potentiates the cytotoxicity of vincristine (Item No. 11764), an anti-cancer alkaloid known to be exported from cells by P-glycoprotein.{31094,21121} Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil (Item No. 14288), a P-glycoprotein inhibitor.{31095,21122} The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.{31095}  

 

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Description

A natural methylated diketopiperazine that potentiates the cytotoxicity of vincristine; directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil, a P-glycoprotein inhibitor, over a range of 1 to 20 µg/ml

Formal name: 1-methyl-3Z,6Z-bis(phenylmethylene)-2,5-piperazinedione

Synonyms: 

Molecular weight: 304.3

CAS: 130603-59-7

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Multidrug Resistance

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