A broad-spectrum β-lactam antibiotic; active against Gram-negative and Gram-positive bacteria

Piperacillin (sodium salt) – 500 mg

Brand:
Cayman
CAS:
59703-84-3
Storage:
-20
UN-No:
Non-Hazardous - /

Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.  

 

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Description

A broad-spectrum β-lactam antibiotic; active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively); active against P. aeruginosa 46220 when used alone or in combination with tazobactam (ED50s = 1.58 and 1.34 mg/animal, respectively) in a mouse model of systemic infection; less active against P. aeruginosa 46220 DR-2 when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively) in a mouse model of systemic infection

Formal name: (2S,5R,6R)-6-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt

Synonyms:  CL 227,193|T-1220

Molecular weight: 539.5

CAS: 59703-84-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Monobactams||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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