Description
A broad-spectrum β-lactam antibiotic; active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively); active against P. aeruginosa 46220 when used alone or in combination with tazobactam (ED50s = 1.58 and 1.34 mg/animal, respectively) in a mouse model of systemic infection; less active against P. aeruginosa 46220 DR-2 when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively) in a mouse model of systemic infection
Formal name: (2S,5R,6R)-6-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt
Synonyms: CL 227,193|T-1220
Molecular weight: 539.5
CAS: 59703-84-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics|Monobactams||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases
