A partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay); potentiates muscle relaxant and hypnotic effects of diazepam in mice; increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity

Pipequaline – 10 mg

Brand:
Cayman
CAS:
77472-98-1
Storage:
-20
UN-No:
Non-Hazardous - /

Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay).{35203} In mice, pipequaline enhances the effects of diazepam (Item No. ISO60177), further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects.{39426} Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil (Item No. 14252).  

 

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Description

A partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay); potentiates muscle relaxant and hypnotic effects of diazepam in mice; increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity ,

Formal name: 2-phenyl-4-[2-(4-piperidinyl)ethyl]-quinoline

Synonyms:  ,PK 8165 ,|45319 RP

Molecular weight: 316.4

CAS: 77472-98-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Seizure Disorders

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