An active metabolite of pioglitazone; formed primarly through CYP2C8-mediated metabolism of pioglitazone

Pioglitazone Ketone – 5 mg

Brand:
Cayman
CAS:
146062-45-5
Storage:
-20
UN-No:
Non-Hazardous - /

Pioglitazone ketone is an active metabolite of the PPARγ agonist pioglitazone (Item Nos. 71745 | 10028 | 22263).{49141,49142,9838} Formation of pioglitazone ketone occurs primarly through cytochrome P450 (CYP) isoform CYP2C8-mediated metabolism of pioglitazone.{49141,49142} Pioglitazone ketone (100 mg/kg in the diet) reduces blood glucose levels in a KKAy mouse model of type 2 diabetes.{9838}  

 

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SKU: 28044 - 5 mg Category:

Description

An active metabolite of pioglitazone; formed primarly through CYP2C8-mediated metabolism of pioglitazone

Formal name: 5-[[4-[2-(5-acetyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Synonyms:  Ketopioglitazone

Molecular weight: 370.4

CAS: 146062-45-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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