A stilbene with diverse biological activities; activates SIRT1 and induces glucose uptake in isolated rat L6 skeletal muscle myotubes; reduces radial growth in a panel of 28 plant pathogenic fungi at 100 μg/ml; reduces expression of MMP-2

Pinosylvin – 1 mg

Brand:
Cayman
CAS:
22139-77-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities.{51006,51007,51008,51009,51010,51011} It activates sirtuin 1 (SIRT1) and induces glucose uptake in isolated rat L6 skeletal muscle myotubes.{51007} Pinosylvin reduces radial growth in a panel of 28 plant pathogenic fungi when used at a concentration of 100 μg/ml.{51008} It reduces expression of matrix metalloproteinase-2 (MMP-2), MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells.{51009} Pinosylvin (10 mg/kg, i.p.) reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer. It decreases hind paw volume and myeloperoxidase (MPO) activity in a rat model of adjuvant-induced arthritis.{51010} Pinosylvin also exhibits plant antifeedant activity against L. americanus (snowshoe hares).{51011}  

 

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Description

A stilbene with diverse biological activities; activates SIRT1 and induces glucose uptake in isolated rat L6 skeletal muscle myotubes; reduces radial growth in a panel of 28 plant pathogenic fungi at 100 μg/ml; reduces expression of MMP-2, MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells; reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer at 10 mg/kg; decreases hind paw volume and MPO activity in a rat model of adjuvant-induced arthritis; exhibits plant antifeedant activity against L. americanus

Formal name: 5-[(1E)-2-phenylethenyl]-1,3-benzenediol

Synonyms:  trans-3,5-Dihydroxystilbene

Molecular weight: 212.2

CAS: 22139-77-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Stilbenes||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation||Research Area|Toxicology|Environmental

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