A flavonoid with diverse biological activities; induces QR in murine hepatoma cells (QR doubling concentration of 500 nM); inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM

Pinostrobin – 5 mg

Brand:
Cayman
CAS:
480-37-5
Storage:
-20
UN-No:
Non-Hazardous - /

Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{37107} It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM.{37108} Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively).{37109} Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).{37110}  

 

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Description

A flavonoid with diverse biological activities; induces QR in murine hepatoma cells (QR doubling concentration of 500 nM); inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively); shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM)

Formal name: 2,3-dihydro-5-hydroxy-7-methoxy-2S-phenyl-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 270.3

CAS: 480-37-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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