Description
A lignan with diverse biological activities; an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 µM in Baker’s yeast and rat small intestine, respectively); scavenges ABTS, but not DPPH, radicals in cell-free assays (IC50s = 13.43 and >200 µg/ml, respectively); cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells (IC50s = 29.35, 62.35, 75.32, >80, and >80 µM, respectively); prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 µM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 µM)
Formal name: 4,4′-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2-methoxy-phenol
Synonyms: NSC 35444
Molecular weight: 358.4
CAS: 487-36-5
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic
