A flavonoid with diverse biological activities; induces apoptosis in

Pinocembrin – 250 mg

Brand:
Cayman
CAS:
480-39-7
Storage:
-20
UN-No:
Non-Hazardous - /

Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities.{52452,52453,52454,52455,52456} It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 µM.{52453} Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH).{52454} It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy.{52455} Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.{52456}  

 

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Description

A flavonoid with diverse biological activities; induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells at 200 µM; reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced ICH at 5 mg/kg; prevents increases in plasma and kidney MDA levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy; reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury at 20 and 50 mg/kg

Formal name: (2S)-2,3-dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Synonyms:  5,7-Dihydroxyflavon|(+)-Pinocembrin|Dihydrochrysin|NSC 279005

Molecular weight: 256.3

CAS: 480-39-7

Purity: ≥95%

Formulation: A solid

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