Description
A flavonoid with diverse biological activities; induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells at 200 µM; reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced ICH at 5 mg/kg; prevents increases in plasma and kidney MDA levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy; reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury at 20 and 50 mg/kg
Formal name: (2S)-2,3-dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Synonyms: 5,7-Dihydroxyflavon|(+)-Pinocembrin|Dihydrochrysin|NSC 279005
Molecular weight: 256.3
CAS: 480-39-7
Purity: ≥95%
Formulation: A solid
