PTA2 is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of TX synthase.{516

Pinane Thromboxane A2 – 1 mg

Brand:
Cayman
CAS:
71111-01-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Pinane thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase.{516,794} PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.{516}  

 

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Description

PTA2 is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of TX synthase.{516,794} PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet TX synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.{516}

Formal name: 9α,11α-(dimethyl)methylene-15S-hydroxy-11a-deoxy-11a-methylene-thromba-5Z,13E-dien-1-oic

Synonyms:  15(S)-Pinane Thromboxane A2|Pinane TXA2|PTA2

Molecular weight: 376.6

CAS: 71111-01-8

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Thromboxanes||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Coronary Artery Disease||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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