A potassium channel opener

Pinacidil (hydrate) – 250 mg

Brand:
Cayman
CAS:
85371-64-8
Storage:
-20
UN-No:
Non-Hazardous - /

Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively.{25813,25181,22674} It completely relaxes coronary artery rings preconstricted with serotonin (Item No. 14332; IC50 = 1.26 µM).{25180} Through this mechanism, pinacidil causes vascular relaxation, decreases peripheral vascular resistance, and reduces hypertension in animals and humans.{25812,25814}  

 

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Description

A potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively; completely relaxes coronary artery rings preconstricted with serotonin (IC50 = 1.26 µM)

Formal name: N-cyano-N’-4-pyridinyl-N”-(1,2,2-trimethylpropyl)-guanidine, monohydrate

Synonyms: 

Molecular weight: 263.4

CAS: 85371-64-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation

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