An alkaloid with diverse biological activities; inhibits deamination of 5-HT by MAO (IC50 = 48 μM); increases the minimum and maximum electroshock seizure thresholds in mice at 80 mg/kg; in a mouse model of tremorine-induced tremors

Pimprinine – 5 mg

Brand:
Cayman
CAS:
13640-26-1
Storage:
-20
UN-No:
Non-Hazardous - /

Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties.{36886,36887,36889,36888} It inhibits deamination of serotonin (5-HT; Item No. 14332) by monoamine oxidase (MAO; IC50 = 48 μM).{36886} Pimprinine (80 mg/kg) increases the minimum and maximum electroshock seizure thresholds in mice.{36887} In a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine when administered at a dose of 80 mg/kg. Pimprinine inhibits aggregation of rabbit platelets induced by arachidonic acid (Item Nos. 90010 | 10006607) or collagen (IC50s = 3 and 25 μg/ml, respectively) and arachidonic acid-induced thromboxane A2 (TXA2) synthesis in rabbit platelets in vitro (IC50 = 6 μg/ml).{36889} It also inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 μg/ml, respectively).{36888,36887}  

 

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SKU: 25507 - 5 mg Category:

Description

An alkaloid with diverse biological activities; inhibits deamination of 5-HT by MAO (IC50 = 48 μM); increases the minimum and maximum electroshock seizure thresholds in mice at 80 mg/kg; in a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine at 80 mg/kg; inhibits aggregation of rabbit platelets induced by arachidonic acid or collagen (IC50s = 3 and 25 μg/ml, respectively) and arachidonic acid-induced TXA2 synthesis in rabbit platelets in vitro (IC50 = 6 μg/ml); inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 μg/ml, respectively)

Formal name: 3-(2-methyl-5-oxazolyl)-1H-indole

Synonyms:  NSC 80793

Molecular weight: 198.2

CAS: 13640-26-1

Purity: ≥95%

Formulation: A powder

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Seizure Disorders

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