A dopamine receptor antagonist (Kis = 2.4

Pimozide – 250 mg

Brand:
Cayman
CAS:
2062-78-4
Storage:
-20
UN-No:
Non-Hazardous - /

Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively).{25512} It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42 and 340 nM, respectively).{25511,26443,26441} Pimozide (0.5, 1, and 2 mg/kg) decreases the number of licks and reduces fluid intake of a sweetened solution in rats.{45613} It decreases the number of threats and attacks and increases immobility time in the neutral arena aggression test, indicating increased passiveness, in male mice when administered at a dose of 0.75 mg/kg for 10 days.{45614} Formulations containing pimozide have been used in the treatment of Tourette syndrome.  

 

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Description

A dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively); binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits Nav1.2 and Kv11.1 (IC50s = 42 and 340 nM, respectively); decreases the number of licks and reduces fluid intake of a sweetened solution in rats at 0.5, 1, and 2 mg/kg; decreases the number of attacks and threats and increases immobility time in the neutral arena aggression test, indicating increased passiveness, in male mice at 0.75 mg/kg for 10 days

Formal name: 1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

Synonyms:  NSC 170984|R 6238

Molecular weight: 461.6

CAS: 2062-78-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Behavioral Neuroscience

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