An inhibitor of influenza virus PB2 (KD = ~1.6 µM) and inhibits the activity of Axl and CaMKIIβ by >50% in a panel of 65 human and rat kinases; decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = 50s = 0.58

Pimodivir – 25 mg

Brand:
Cayman
CAS:
1629869-44-8
Storage:
-20
UN-No:
Non-Hazardous - /

Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; KD = i = ~1.6 µM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = 16070), zanamivir (Item No. 15123), and favipiravir (T-705; Item No. 23384) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay.{52123} Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.  

 

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Description

An inhibitor of influenza virus PB2 (KD = ~1.6 µM) and inhibits the activity of Axl and CaMKIIβ by >50% in a panel of 65 human and rat kinases; decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = 50s = 0.58, 0.64, and 0.89, respectively, in a cell-based assay); increases survival in a mouse model of intranasal influenza A infection at 1, 3, and 10 mg/kg twice per day

Formal name: (2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-bicyclo[2.2.2]octane-2-carboxylic acid

Synonyms:  JNJ 63623872|JNJ 872|VX 787

Molecular weight: 399.4

CAS: 1629869-44-8

Purity: ≥98%

Formulation: A solid

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