Description
A 5-HT2A inverse agonist (IC50 = 1.86 nM; Ki = 0.5 nM); selective for 5-HT2A over a panel of 65 ion channels, enzymes, and receptors (Kis = >100 nM); reduces DOI-induced head-twitch behavior and prepulse inhibition deficits in rats at doses of 3 mg/kg, p.o. and 1-10 mg/kg, s.c., respectively; exhibits antipsychotic-like activity, reducing (+)-MK-801-induced hyperactivity in mice; acts synergistically with haloperidol or risperidone to suppress (+)-MK-801-induced hyperactivity and attenuates haloperidol- and risperidone-induced catalepsy in rats
Formal name: N-[(4-fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N’-[[4-(2-methylpropoxy)phenyl]methyl]-urea
Synonyms:
Molecular weight: 427.6
CAS: 706779-91-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease
