A resin acid; reduces mRNA expression

Pimaric Acid – 1 mg

Brand:
Cayman
CAS:
127-27-5
Storage:
-20
UN-No:
Non-Hazardous - /

Pimaric acid is a resin acid that has been found in A. cordata and various pines.{43600,43601} It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM.{43600} Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.  

 

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SKU: 26062 - 1 mg Category:

Description

A resin acid; reduces mRNA expression, protein levels, and promoter activity of MMP-9 in TNF-α-stimulated HASMCs from 5-20 μM; reduces nuclear expression and binding of NF-κB and AP-1 to the MMP-9 promoter in HASMCs from 10-20 μM; reduces TNF-α-induced HASMC migration to control levels at 20 μg/ml

Formal name: (1R,4aR,4bS,7S,10aR)-7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenecarboxylic acid

Synonyms:  8(14),15-Pimaradien-18-oic acid|NSC 2956

Molecular weight: 302.5

CAS: 127-27-5

Purity: ≥90%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Research Area|Immunology & Inflammation

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