A pan-Pim kinase inhibitor (Kis = 6

PIM447 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1820565-69-2
Storage:
-20
UN-No:
Non-Hazardous - /

PIM447 is a pan-Pim kinase inhibitor (Kis = 6, 18, and 9 pM for Pim-1, Pim-2, and Pim-3, respectively).{52390} It is selective for Pim kinases over a panel of 383 non-mutant kinases at 1 µM. PIM447 inhibits cell growth in a panel of 26 acute myeloid leukemia (AML) cell lines (GI50s = 0.01-8.66 µM). In vivo, PIM447 (30 and 100 mg/kg) reduces tumor growth and phosphorylation of the Pim kinase target pS6RP in a KG-1 AML mouse xenograft model. It also reduces the tumor burden and prevents tumor-associated bone loss in a mouse model of bone marrow-disseminated human multiple myeloma.{52391}  

 

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SKU: 29718 - 1 mg Category:

Description

A pan-Pim kinase inhibitor (Kis = 6, 18, and 9 pM for Pim-1, Pim-2, and Pim-3, respectively); selective for Pim kinases over a panel of 383 non-mutant kinases at 1 µM; inhibits cell growth in a panel of 26 AML cell lines (GI50s = 0.01-8.66 µM); reduces tumor growth and phosphorylation of the Pim kinase target pS6RP in a KG-1 AML mouse xenograft model at 30 and 100 mg/kg; reduces the tumor burden and prevents tumor-associated bone loss in a mouse model of bone marrow-disseminated human multiple myeloma

Formal name: N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide, dihydrochloride

Synonyms: 

Molecular weight: 513.4

CAS: 1820565-69-2

Purity: ≥98%

Formulation: A crystalline solid

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