A selective inhibitor of Vps34 (PI3K type 3; IC50 = 18 nM); acutely inhibits autophagy and de novo lipidation of LC3

PIK-III – 5 mg

Brand:
Cayman
CAS:
1383716-40-2
Storage:
-20
UN-No:
Non-Hazardous - /

PIK-III is an inhibitor of the type 3 phosphatidylinositol 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) that binds a unique hydrophobic pocket (IC50 = 18 nM).{27535} It is selective for Vps34 over related PI3K isoforms, PI4Kβ, and mTOR. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, leading to stabilization of autophagy substrates.{27535}  

 

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Description

A selective inhibitor of Vps34 (PI3K type 3; IC50 = 18 nM); acutely inhibits autophagy and de novo lipidation of LC3, leading to stabilization of autophagy substrates

Formal name: 4′-(cyclopropylmethyl)-N2-4-pyridinyl-[4,5′-bipyrimidine]-2,2′-diamine

Synonyms:  Vacuolar Protein Sorting 34 Inhibitor 2|Vps34 Inhibitor 2|Vps34-IN2

Molecular weight: 319.4

CAS: 1383716-40-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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